Articles

• What Are Organic Acids? - Organic acids are products of metabolism that can sensitively identify nutrient deficiencies that lead to metabolic roadblocks.
• Important Markers of Neurological Inflammation: Kynurenate & Quinolinate - The kynurenine (KYN) pathway is a major route of L-tryptophan catabolism and operates as a mechanism of defense against intracellular pathogens and as a mediator of stress response signals to the brain.
• Mitochondrial Dysfunction and Disease - This article examines the structure and function of mitochondria, details the mechanisms by which acquired mitochondrial dysfunction can create a wide range of symptoms and provides a rational approach to treatment.
• Assessment of Biochemical and Nutritional Individuality through Organic Acid Testing - Organic acid testing provides a broad view of many important bodily functions amenable to nutritional interventions. One urine sample can be used to evaluate dysbiosis, detoxification, and nervous system transmitter balance as well as multiple nutrient deficiencies.
• Significance of Urinary Tartaric Acid - Letter to the editor of Clinical Chemistry supporting the claim that urinary tartaric acid is not a valid measure of yeast overgrowth.
• Autistic Therapies Focused by Laboratory Data - This review focuses on laboratory evaluation of organic acidurias for revealing metabolic weaknesses in autism that may be responsive to aggressive nutritional, detoxification and gastrointestinal immune balancing interventions.
• Urinary Markers of Intestinal Yeast - Letter to the editor of Towsend Letter for Doctors and Patients gives the argument against the use of urinary arabinose for detection of invasive candidiasis and for the use of urinary D-arabinitol instead.
• Urinary Markers of Yeast Overgrowth - This paper presents a review of scientific reports of some urinary markers of yeast overgrowth.

Books

• ADD & ADHD Complementary/Alternative Medicine Solutions - This book is a complete how-to guide of no-nonsense, science-based approach to ADHD. The book is designed to help most people get rapid results using natural non-drug interventions.
• End Your Addiction Now - This book explains the "Quick Start" stage of the Power Recovery Program, which helps reduce or eliminate substance abuse cravings within 24-72 hours. The Program is now being used by residential treatment centers, private practitioners and individuals nationwide. This book further discusses ways to reverse damage and restore health.
• Laboratory Evaluations for Integrative and Functional Medicine - Your evidence-based resource for the biochemical basis of chronic illness. A must-have desk reference for laboratory testing associated with nutritional and metabolic medicine.

Case Studies

• High 2-methylhippurate and Low Sulfate - Xylene exposure found in elevated levels of 2-methylhippurate and low levels of sulfate.
• The TRIAD Profile in Depression and Migraine Headache: A Case Study - Standard medical treatments for major depressive disorder and migraine headache are only partially effective. Clinical improvement requires correction of underlying metabolic difficulties. This case illustrates the power of multiple markers to focus on key metabolic issues.
• 8-Year Multiple Sensitivity, Oxidative Stress - Multiple abnormalities in a woman with multiple sensitivities.
• Follow-up with Autistic Child - Following an autistic child though testing over two-and-a-half years.
• Probiotic Sensitivity - Profound elevation of 5-HIA suggests a bowel-specific serotonin syndrome that is producing a hypersensitivity to changes in the bacterial colonies of the gut.
• 8-Year Pizza-Yeast Connection - Case of severe yeast overgrowth due to overconsumption of high carbohydrate food.
• Myasthenia Gravis Three Year Tracking - With myasthenia gravis, halting the progression is a big deal, and evidence of metabolic improvement gives encouragement.
• Fungal Overgrowth but not Invasive Candidiasis - This case involved a 46-year-old female who was overweight and had poor muscle tone. She presented originally with chronic, severe headaches They improved with pressure and with the use of prednisone. This issue began at age 25.
• Congenital Hypotonia - Evidence of profound mitochondrial oxidation lesions are seen in this infant with breathing difficulties.
• Dysbiosis from Corticosteroid Use - The common assumption that prolonged courses of corticosteroid treatment can precipitate Candida yeast infections have never been so evident as in this case.
• Biotin & Detoxification Needs in Cognitively Delayed Adult - Biotin deficiency may be linked to hyperlipidemia and up-regulated fatty acid desaturation in this mildly psychotic man.
• Ice-in-veins 5HTP Aberrations - Specific points of metabolic aberrations appear in a man using high doses of 5-hydroxytryptophan for sleep.
• Extreme Arabinitol - Extreme elevation of D-arabinitol presents an potential explanation of otherwise unexplained and unusual chronic symptoms.
• Yeast - Nitric Oxide Pattern - A possible case of autism and several metabolic markers that can be improved.
• Prader-Willi-2 - Mitochondrial distress with oxidative stress and extreme glutathione up-regulation is exacerbated by glycine conjugation insufficiency and intestinal bacterial overgrowth.
• Prader-Willi 1 - A series of Organix reports shows the nature of this genetic abnormality as numerous, severe, and persistent metabolic disturbances.
• Philadelphia Chromosome - When follow up testing looks much worse while a young leukemia patient is improving, multiple factors are at play. Underlying dysbiosis and glutathione issues are involved in this case.
• D-Lactate Study Set - Seven cases illustrate a variety of other bacterial marker abnormalities when D-lactate is high. The patterns instruct about etiologies and intervention strategies.
• High Amino Developmental Delay - A combination of environmental, nutritional, and genetic metabolic weaknesses were found as potential causative factors in the failure of neurological development for this 2-year-old girl. Vitamin B6 insufficiency, arsenic exposure, and intestinal dysbiosis are key features in the initial laboratory workup.
• Antibiotic-induced D-lactic Aciduria - Supplementation with L. acidophillus in a child with carbohydrate absorption difficulties can produce an encephalopathic syndrome associated with D-lactic acidemia. Testing shown in this case spans over the interval of time where urinary D-lactate was added to the Organix report.
• Huntington's Disease - Curious fatty acid desaturation patterns are found as a major feature of mild abnormalities found in this progressive neurodegenerative disease.
• Adrenal Stress – Biotin Pattern - Interesting combination of test markers link cortisol level to biotin deficiency and small bowel bacterial overgrowth.

Metabolic Pathways

• Citric Acid Cycle - Markers of Coenzyme Q10 Synthesis and Function Elevation of organic acids in urine can reveal inhibition of the coenzyme Q10 biosynthetic pathway (A) or interruptions of the electron transport system (B) from inability to sustain adequate CoQ10 levels in the inner mitochondrial membrane.

Podcasts

• How do toxins affect mitochondria? - Part 3 - In this third installment of my conversation with Dr. Walter Crinnion, we consider the function of the mitochondria, those “cellular power plants” that provide most of our cell’s supply of adenosine triphosphate (ATP).
• Immunotoxicity - First to the party - Part 4 - We take a deeper look into how toxins affect the immune system this week. Dr. Crinnion says immunotoxicity is usually the first problem that shows up in a person’s history, typically manifesting itself as allergies or asthma...
• Hey Fathead, your brain is an easy target for toxins - Part 5 - The brain is one of the largest fatty organs in our body. Dr. Crinnion says that many environmental toxins are fat-soluble and easily pass the blood/brain barrier.
• Who’s your mama? Is your generation at risk? - Part 6 - The endocrine system is another major target of environmental compounds. Did you know this system directly affects fertility and reproduction? Dr. Crinnion shares a story about the result of persistent, man-made chemicals being transferred from across generations...
• Which test is best? - Part 7 - With so many tests available to clinicians, it can be overwhelming for them to determine which one is the best for their patients. In this podcast, Dr. Crinnion gives his suggestions on testing for toxic exposure.
• Autism and Laboratory Testing - April is the month where many organizations focus on raising awareness of autism, and Metametrix would like to contribute by generating awareness of the laboratory tests that can help to uncover metabolic factors that may be treated in each individual with this complex disease.
• Finding Pieces of the Puzzle - An interview with Dr. Todd LePine, board certified in Internal Medicine with advanced training and experience in Integrative Functional Medicine.
• Gut-Brain Connection: An Inside Look at Depression - During a recent Metametrix sponsored breakfast at the IFM Symposium in Hollywood, Florida, Dr. Todd LePine gave a compelling presentation entitled the Gut-Brain Connection: An Inside Look at Depression.
• Naturopathic Approaches to Pain Patients - In this edition of Clinician’s Corner, Dr. Kara Fitzgerald, ND shares her clinical tools and treatments that have resulted in remarkable improvement for patients who had otherwise given up all hope of getting better.
• Nutrition Intervention for Autism - Part III - Nutritional interventions have helped many children with ASD on their road to recovery and improved function. In this 3 part interview, Kara Fitzgerald, ND and Julie Matthews, CNC, discuss the common biochemical patterns seen in children with ASD.
• Nutrition Intervention for Autism - Part II - Nutritional interventions have helped many children with ASD on their road to recovery and improved function. In this 3 part interview, Kara Fitzgerald, ND and Julie Matthews, CNC, discuss the common biochemical patterns seen in children with ASD.
• Nutrition Intervention for Autism - Part I - Nutritional interventions have helped many children with ASD on their road to recovery and improved function. In this 3 part interview, Kara Fitzgerald, ND and Julie Matthews, CNC, discuss the common biochemical patterns seen in children with ASD.

Presentations

• Evaluating Environmental Effects on the Body's Biochemistry and Cancer - This presentation explores the impact of environmental toxins on the body's metabolism. There are over 80,000 chemicals on the market that we are exposed to, with the added insult of combined exposures being more toxic to the body. Metametrix testing is explored and various analytes are explained as markers for toxicity.
• Building the Organix Profile Into Clinical Practice - An educational module for users of the Metametrix Urinary Organic Acid (Organix) Profile. Covers the 7 steps of an Organix evaluation.
• Laboratory Markers of Toxins and Detoxification - PowerPoint presentation on the detection of toxic burden in the body.
• IFM: The New Paradigm of Medicine - This PowerPoint presentation was developed by the Institute for Functional Medicine. It provides a concise explanation of the new paradigm of medicine that focuses on underlying causes of disease and treatment from that level rather treating symptoms alone, the approach often taken by modern medicine.
• Functional Nutritional Assessment Using Organic Acid Analysis - Dr. Bralley briefly discusses what organic acids are and the importance of organic acid analysis. Additionally, Dr. Bralley discusses how they can play a key role in improving patient's health in a clinical practice.
• Combining Organix (Dysbiosis) and GI Effects Profiles - Richard Lord and Kara Fitzgerald discuss five cases demonstrating how two different testing areas, gastrointestinal and organic acid profiles, can be used together to diagnose a patient.
• Evaluating the Complex Patient with Organix Testing - Four cases are presented in this teleconference: an autistic child, a child with mitochondrial myopathy, an adult with depression and a professional athlete. Aspects of their organic acid tests are focused on.
• Patching the Leaky Gut: Evaluating Intestinal Microbial Burden using Organic Acids - Four cases using Organix testing: Lyme disease, regressive autism, chronic fatigue/fibromyalgia syndrome, Melnick-Needle
• Nourishing Hope: Nutrition Intervention for Autism Part II - Continuation of Julie Matthews first interview with Dr. Kara Fitzgerald. Metabolic imbalances in autism and their many causes are discussed.
• From Simple Headaches to Cancer: Assessing the Role of Toxic Burden in Disease - The detoxification markers of the Organix profile are discussed, along with five cases.
• Nourishing Hope: Nutrition Intervention for Autism Part III - Continuation of Julie Matthews second interview with Dr. Kara Fitzgerald. Metabolic imbalances in autism and their many causes are discussed.
• Evaluating Oxidative Stress in Chronic Degenerative Conditions: From Autism to Aging- Oxidative stress markers are discussed. Oxidative stress is explained and four cases are presented.
• Evaluating B Vitamin Status in Autism - The B vitamin markers of the Organix test are discussed and their relation to autism. Two autism cases are also discussed.
• Evaluating Neurotransmitter Status in Neuropsychological and Physiological Complaints - Neurotransmitter markers in the Organix test are discussed along with five cases.
• Evaluating Mitochondrial Function and Disease: Managing the Fatigued Patient - The mitochondrial function markers of the Organix test are discussed. Deficiency markers are explained, as well as the supplements used to correct the deficiencies.
• Wellness Hour - Dr. Bralley Interview - Dr. J. Alexander Bralley participates in an interview with Randy Alvarez of The Wellness Hour, the leader in health news and information. This interview takes place at the 2005 IFM International Symposium in California. View this video from Dr. Bralley as he discusses who Metametrix is and the testing services provided.